Lutz Lab
Point-of-care diagnostics for
global health
Positions available with Lutz Labs
The Lutz group is recruiting postdoctoral researchers and research engineers to develop novel point-of-care diagnostics for global health and home testing. We have multiple projects in areas of HIV, respiratory infection (including Covid-19), and other infectious diseases. We are looking for strong thinkers who can contribute in the following areas:
- Point of care device engineering (mechanical prototyping, optical detection, low-cost electrical design)
- Development of novel assays (RNA/DNA detection, nucleic acid amplification)
Please send your CV to Dr. Lutz with the subject “Lutz Lab Hiring 2021”
Please send your CV to Dr. Lutz with the subject “Lutz Lab Hiring 2021”
Publications
Representative peer-reviewed journal publications
Ultrasensitive hybridization capture: Reliable detection of <1 copy/mL short cell-free DNA from large-volume urine samples
Diagnosing pulmonary tuberculosis using sequence-specific purification of urine cell-free DNA
Near point-of-care, point-mutation test to detect drug resistance in HIV-1: a validation study in a Mexican cohort
The Seattle Flu Study: a multi-arm community-based prospective study protocol for assessing influenza prevalence, transmission, and genomic epidemiology
OLA-Simple: A software-guided HIV-1 drug resistance test for low-resource laboratories
Analytical Comparison of Methods for Extraction of Short Cell-Free DNA from Urine
1775. A Community-wide Study to Evaluate the Accuracy of Self-testing for Influenza: Works in Progress
Threshold-Based Quantification in a Multiline Lateral Flow Assay via Computationally Designed Capture Efficiency
Frequency characterization of flow magnitude and phase in resonant microfluidic circuits
Frequency tuning allows flow direction control in microfluidic networks with passive features
Flow control using audio tones in resonant microfluidic networks: towards cell-phone controlled lab-on-a-chip devices
Simplified paper format for detecting HIV drug resistance in clinical specimens by oligonucleotide ligation
Isothermal Strand Displacement Amplification (iSDA): A Rapid and Sensitive Method of Nucleic Acid Amplification for Point-of-Care Diagnosis
One-step purification and concentration of DNA in porous membranes for point-of-care applications
A versatile valving toolkit for automating fluidic operations in paper microfluidic devices
Swab Sample Transfer for Point-Of-Care Diagnostics: Characterization of Swab Types and Manual Agitation Methods
Long-term dry storage of an enzyme-based reagent system for ELISA in point-of-care devices
Dissolvable fluidic time delays for programming multi-step assays in instrument-free paper diagnostics
Subject of a “Viewpoints” article by George Whitesides, Lab on a Chip (2013), DOI: 10.1039/C3LC90066e. Also featured in Chemistry World, May 30, 2013, ”Microfluidic sugar paper” with quotes from George Whitesides
A Rapid, Multiplexed, High-Throughput Flow-Through Membrane Immunoassay: A Convenient Alternative to ELISA
New and Improved Ways to Treat Hydrocephalus: pursuit of a smart shunt
Progress toward multiplexed sample-to-result detection in low resource settings using microfluidic immunoassay cards
Two-dimensional paper networks: programmable fluidic disconnects for multi-step processes in shaped paper
Enhanced Sensitivity of Lateral Flow Tests Using a Two-Dimensional Paper Network Format
Transport in two-dimensional paper networks
Microfluidics without pumps: re-inventing the T-sensor & H-filter in paper networks
Chemical signal amplification in two-dimensional paper networks
Visualization and measurement of flow in two-dimensional paper networks
Controlled reagent transport in disposable 2D paper networks
Rapid protein depletion from complex samples using a bead-based microfluidic device for the point of care
People
Current lab members
Barry Lutz
Assistant Professor
Bob Atkinson
BioE Ph.D. Student
Point-of-care multiplexable nucleic acid assay for STDs
Nuttada Panpradist
BioE Ph.D. Student
OLA-Simple – HIV Drug Resistance Test
Ian Hull
BioE Ph.D. Student
Daniel Leon
Research Engineer
CrossLife TARA detection projects
TB-drug adherence at-home monitoring projectNews
Updates from the inside and around the lab
Nuttada Panpradist Receives UW College of Engineering Award
2021
June 7
Congratulations to Nuttada for being recognized for outstanding contributions to UW Bioengineering research! The UW College of Engineering Awards acknowledged the extraordinary efforts of the college’s teaching and research assistants, staff and faculty members.
Nuttada Panpradist’s impressive academic career includes 13 publications, 17 conference proceedings, and four patent applications. Her simple point-of-care tests detect HIV genetic mutations to help doctors prescribe non-resistant drugs. She designed rapid lab tests for COVID-19 and devices to ensure patients are taking their TB medication. She has collaborated with various researchers on COVID-19 projects such as developing new methods to detect SARS-CoV-2 in Seattle to validating point-of-care tests in pediatric clinics. As a mentor, Panpradist connects undergraduate students with research projects that match their interests. All her students have received research scholarships and are named as co-authors and co-inventors of patents. “Nuttada has gone above and beyond to foster our new collaboration; beyond her scientific acumen, she is an attentive and professional partner, mature beyond her years, conscientious, flexible, able to balance multiple responsibilities, and has an impressive work ethic.”05/26
Amy passed her Ph.D. defense, titled "Improving diagnosis of tuberculosis from urine cell-free DNA." Congratulations Amy!"
02/01
Nuttada's paper from 2014 on swabs for point-of-care testing is getting a lot of attention lately. She characterized the release of samples from different nasal swab types, including the effect of manual agitation and a novel design for flow through swabs - very relevant today for Covid testing. She is working on a follow-up paper - coming soon!
202003/27
The Lutz group is recruiting for postdoctoral researchers and research engineers to develop novel point of care diagnostics for global health and home testing. We have multiple projects in areas of HIV, respiratory infection (including Covid-19), and other infectious diseases. We are looking for strong thinkers who can contribute in the following areas:- Point of care device engineering (mechanical prototyping, optical detection, low-cost electrical design)
- Development of novel assays (RNA/DNA detection, nucleic acid amplification)
Please send your CV to Dr. Lutz with the subject “Lutz Lab Hiring 2020”
2018
03/08
Rahil passed his defense. Congratulations!
03/01
OLA Simple won the 2nd place $10k award at the annual Health Innovation Challenge
2017
09/09
Dr. Lutz traveled to Nepal as part of a Bioengineering department group to make ties to Kathmandu University.
09/01
Rahil's paper on the flow magnitude and phase measurement in resonant devices is published and selected to be featured on the Front Cover of the Journal Analytical Methods.
http://pubs.rsc.org/en/content/articlelanding/2017/ay/c7ay01699a#!divAbstract
08/22 - 09/15
Rahil got the Amazon Catalyst grant ($50k) and the GIX Innovation Award ($20k) to further work on commercializing his side projects.
08/15
Dr. Nathan White (UW, Emergency medicine) and Dr. Lutz submitted a new collaboration grant to work on a smartphone-powered thromboelastography device based on the resonant microfluidics project.
07/14
Nuttada received the prestigious 2017 UW Medicine Bud Tribble and Susan Barnes Graduate Discovery Fellowship. To learn more: https://bioe.uw.edu/nuttada-panpradist-receives-graduate-discovery-fellowship/
05/01
Rahil's paper featured on the Front Cover of the Journal Lab on a Chip Volume 17 Number 9
http://pubs.rsc.org/en/content/articlelanding/2017/lc/c7lc90043k#!divAbstract
News article - https://bioe.uw.edu/ph-d-student-rahil-jain-investigates-smart-solutions-for-diagnostics-home-electronics/
04/27
Nuttada passed her Generals! Congratulations!
03/06
Dr. Lutz traveled to Bangladesh to experience the global health needs first-hand.
02/06
Nuttada and her OLA-Simple team were featured on KIRO NEWS
https://www.engr.washington.edu/news/panpradist
01/28
Rahil passed his Generals. Congratulations!
2016
08/31
Congratulation to Nuttada and Rahil for being selected as 10 finalists around the nation for the APF Student Technology Prize for Primary Healthcare. The competition, administered by Massachusetts General Hospital's Ambulatory Practice of the Future (APF) and sponsored by the Gelfand Family Charitable Trust, encourages and supports engineering students' efforts to develop innovative, clinically-relevant primary health care technology concepts.
06/10
Congratulations to Doan and Ian on graduating. Ian made it to coveted Husky 100 and is heading to MIT for graduate school. Doan will be working with Physio Control in Redmond WA. Good luck to you both.
05/12
Congratulations to Nuttada and Rahil to make it final round of APF Student Technology Prize. Both are independently getting $10k to further their research. Final proposals are due Aug 29.
03/11
Congratulations to Annie on receiving Mary Gates Research Scholarship!
02/12
Nuttada and Dr. James Lai (our collaborator on the OLA-Simple Project) wrote a chapter on point-of-care diagnostics as part of the book titled "Biomaterials Nanoarchitectonics" edited by Mitsuhiro Ebara. The book has just been published and now available at Elsevier website and can be downloaded via the UW library.
02/01
Bioengineer sophomore Jonathan Lim joined the Lutz Lab and will work on the TB project. Welcome Jonathan!!!
01/11
Nuttada's manuscript in PLoS ONE! "Simplified paper format for detecting HIV drug resistance in clinical specimens by oligonucleotide ligation" - see publications
02/20 - 02/21
Nuttada, Annie, Ian and Nikki are presenting at the XXV International HIV Drug Resistance Workshop in Boston, MA (a closed workshop, with a limited attendance of 200 delegates). Stop by and check out their poster presentations in the New Resistance Technologies and Interpretations Session!
01/20
Nuttada is co-lecturing with Dr. Sylvia LaCourse in the GH590 Global WACh BioEngineering Seminar on "Opportunities for Point-of-care TB Diagnostics" Come by at 4:30 - 5:30 PM at EEB 037 in the Electrical Engineering Building!
01/04 - 03/11
Dr. Lutz is teaching the Global Health Technology: Molecular Diagnostics!
01/04 - 03/11
Nuttada is TAing for BIOEN 531 Proposal Writing by Dr. Marta Scatena - one of the three Bioengineering Graduate Core classes! She is teaching a class on oral presentation and grant reviewing process on the Feb 8th, 2015.
2016
08/31
Congratulation to Nuttada and Rahil for being selected as 10 finalists around the nation for the APF Student Technology Prize for Primary Healthcare. The competition, administered by Massachusetts General Hospital's Ambulatory Practice of the Future (APF) and sponsored by the Gelfand Family Charitable Trust, encourages and supports engineering students' efforts to develop innovative, clinically-relevant primary health care technology concepts.
06/10
Congratulations to Doan and Ian on graduating. Ian made it to coveted Husky 100 and is heading to MIT for graduate school. Doan will be working with Physio Control in Redmond WA. Good luck to you both.
05/12
Congratulations to Nuttada and Rahil to make it final round of APF Student Technology Prize. Both are independently getting $10k to further their research. Final proposals are due Aug 29.
03/11
Congratulations to Annie on receiving Mary Gates Research Scholarship!
02/12
Nuttada and Dr. James Lai (our collaborator on the OLA-Simple Project) wrote a chapter on point-of-care diagnostics as part of the book titled "Biomaterials Nanoarchitectonics" edited by Mitsuhiro Ebara. The book has just been published and now available at Elsevier website and can be downloaded via the UW library.
02/01
Bioengineer sophomore Jonathan Lim joined the Lutz Lab and will work on the TB project. Welcome Jonathan!!!
01/11
Nuttada's manuscript in PLoS ONE! "Simplified paper format for detecting HIV drug resistance in clinical specimens by oligonucleotide ligation" - see publications
02/20 - 02/21
Nuttada, Annie, Ian and Nikki are presenting at the XXV International HIV Drug Resistance Workshop in Boston, MA (a closed workshop, with a limited attendance of 200 delegates). Stop by and check out their poster presentations in the New Resistance Technologies and Interpretations Session!
01/20
Nuttada is co-lecturing with Dr. Sylvia LaCourse in the GH590 Global WACh BioEngineering Seminar on "Opportunities for Point-of-care TB Diagnostics" Come by at 4:30 - 5:30 PM at EEB 037 in the Electrical Engineering Building!
01/04 - 03/11
Dr. Lutz is teaching the Global Health Technology: Molecular Diagnostics!
01/04 - 03/11
Nuttada is TAing for BIOEN 531 Proposal Writing by Dr. Marta Scatena - one of the three Bioengineering Graduate Core classes! She is teaching a class on oral presentation and grant reviewing process on the Feb 8th, 2015.
