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Lutz Lab

Point-of-care diagnostics for

global health

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  • Welcome to Lutz Lab

    Simple phenomena + clinical need + real-world constraints

    As bioengineers we seek to apply scientific understanding to develop technology for improving human health. Our work is defined by manipulation of simple physical and biochemical phenomena to create devices for unmet clinical needs, and attention to real-world constraints improves the chances that our work will impact patients. The interplay between science, technology, clinical need, and real-world constraints creates a puzzle that requires a disciplined form of creativity and invention.

  • News

    Updates from the inside and around the lab

    2023

     

    June

    Nuttada Panpradist is featured by Brotman Baty Institute in Promising Yount Scientists as a Profile in Courage.

     

  • Publications

    Representative peer-reviewed journal publications

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    Development of a Highly Multiplexed RT-LAMP Assay for Coverage of Genetic Sequence Diversity

    Shane D. Gilligan-Steinberg, Enos C. Kline, Qin Wang, Rhett J. Britton, Wookyeom Kim, Jason W. Rupp, Hanwen Gu, Ingrid A. Beck, Ian T. Hull, Nuttada Panpradist, Joanne D. Stekler, Lisa M. Frenkel, Paul K. Drain, James J. Lai, Barry R. Lutz
    Analytical Chemistry, (February 2025) • ACS Publications

    https://doi.org/10.1021/acs.analchem.4c05583

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    Simplified MS2 phage-like particle production including a novel maturation protein internal fusion affinity tag

    Enos C. Kline, Rose Duong,Qin Wang, Barry R. Lutz
    Biotechnology & Biotechnological Equipment Vo. 39, 2025 - Issue 1 (February 2025)

    https://doi.org/10.1080/13102818.2025.2457691

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    Large-volume RT-LAMP enables extraction-free amplification of HIV RNA from fingerstick plasma

    Qin Wang, Shane D. Gilligan-Steinberg, Wookyeom Kim, Enos C. Kline, Ian T. Hull, James J. Lai, Barry R. Lutz
    Analytica Chimica Acta Volume 1307, 8 (June 2024) https://doi.org/10.1016/j.aca.2024.342560

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    Sensitive Pathogen Detection and Drug Resistance Characterization Using Pathogen-Derived Enzyme Activity Amplified by LAMP or CRISPR-Cas

    Qin Wang, Enos C. Kline, Shane D. Gilligan-Steinberg, James J. Lai, Ian T. Hull, Ayokunle O. Olanrewaju, Nuttada Panpradist, Barry R. Lutz
    Medrxiv.org (Pre-print)
    https://doi.org/10.1101/2024.03.29.243050855

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    Patient-centered mobile tuberculosis treatment support tools (TB-TSTs) to improve treatment adherence: A pilot randomized controlled trial exploring feasibility, acceptability and refinement needs

    Sarah J Iribarren, Hannah Milligan, Cristina Chirico, Kyle Goodwin, Rebecca Schnall, Hugo Telles, Alejandra Iannizzotto, Myrian Sanjurjo, Barry R. Lutz, Kenneth Pike, Fernando Rubinstein, Marcus Rhodehamel, Daniel Leon, Jesse Keyes, George Demiris
    The Lancet Regional Health - Americas (Sept. 2022)
    https://doi.org/10.1016/j.lana.2022.100291

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    Multiplex Target-Redundant RT-LAMP for Robust Detection of SARS-CoV-2 Using Fluorescent Universal Displacement Probes

    Enos C. Kline, Nuttada Panpradist, Ian T. Hull, Qin Wang, Amy K. Oreskovic, Peter D. Han, Lea M. Starita, Barry R. Lutz.
    ASM Journals: Microbiology Spectrum (June 2022)
     
    https://doi.org/10.1128/spectrum.01583-21

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    Simultaneous monitoring of HIV viral load and screening of SARS-CoV-2 employing a low-cost RT-qPCR test workflow

    Gaurav K. Gulati, Nuttada Panpradist, Samuel W. A. Stewart, Ingrid A. Beck, Ceejay Boyce, Amy K. Oreskovic, Claudia García-Morales, Santiago Avila-Ríos, Peter D. Han, Gustavo Reyes-Terán, Lea M. Starita, Lisa M. Frenkel, Barry R. Lutz, and James J. Lai
    Royal Society of Chemistry (June 17, 2022)
    https://doi.org/10.1039/D2AN00405D

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    Aptamer Sandwich Lateral Flow Assay (AptaFlow) for Antibody-Free SARS-CoV-2 Detection

    Lucy F. Yang, Nataly Kacherovsky, Nuttada Panpradist, Ruixuan Wan, Joey Liang, Bo Zhang, Stephen J. Salipante, Barry R. Lutz, and Suzie H. Pun
    Analytical Chemistry (May 9, 2022)
    https://doi.org/10.1021/acs.analchem.2c00554

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    The impact of a rapid home test on telehealth decision-making for influenza: a clinical vignette study

    Xinyan Cai, Mark H. Ebell, Rachel E. Geyer, Matthew Thompson, Nicole L. Gentile & Barry Lutz
    BMC primary care 23 (1), 1-11 (April 13, 2022)
    https://doi.org/10.1186/s12875-022-01675-1

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    Requirements and Study Designs for US Regulatory Approval of Influenza Home Tests

    Tony Yang, Larry G. Kessler, Matthew J. Thompson, Barry R. Lutz
    Journal of Clinical Microbiology 60 (5), e01884-21 )(March 18, 2022)
    https://doi.org/10.1128/jcm.01884-21

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    Diagnostic Accuracy of an At-Home, Rapid Self-test for Influenza: Prospective Comparative Accuracy Study

    Geyer RE, Kotnik JH, Lyon V, Brandstetter E, Zigman Suchsland M, Han PD, Graham C, Ilcisin M, Kim AE, Chu HY, Nickerson DA, Starita LM, Bedford T, Lutz B, Thompson MJ
    JMIR public health and surveillance 8 (2), e28268 (Feb. 22, 2022)
    https://doi.org/10.2196/28268

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    Isothermal Amplification with a Target-Mimicking Internal Control and Quantitative Lateral Flow Readout for Rapid HIV Viral Load Testing in Low-Resource Settings

    Ian T. Hull, Enos C. Kline, Gaurav K. Gulati, Jack Henry Kotnik, Nuttada Panpradist, Kamal G. Shah, Qin Wang, Lisa Frenkel, James Lai, Joanne Stekler, and Barry R. Lutz
    Analytical Chemistry 94 (2), 1011-1021 (Dec. 17, 2021)
    https://doi.org/10.1021/acs.analchem.1c03960

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    A systematic review of clinical prediction rules for the diagnosis of influenza

    Mark H. Ebell, Ivan Rahmatullah, Xinyan Cai, Michelle Bentivegna, Cassie Hulme, Matthew Thompson and Barry Lutz
    The Journal of the American Board of Family Medicine 34 (6), 1123-1140 (Nov. 2021)
    https://doi.org/10.3122/jabfm.2021.06.210110

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    Characterizing the molecular composition and diagnostic potential of Mycobacterium tuberculosis urinary cell-free DNA using next-generation sequencing

    Amy Oreskovic, Adam Waalkes, Elizabeth A. Holmes, Christopher A. Rosenthal, Douglas P.K. Wilson, Adrienne E. Shapiro, Paul K. Drain, Barry R. Lutz, Stephen J. Salipante

    International Journal of Infectious Diseases 112, 330-337 (Nov. 2021)
    https://doi.org/10.1016/j.ijid.2021.09.042

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    Evaluating an app-guided self-test for influenza: lessons learned for improving the feasibility of study designs to evaluate self-tests for respiratory viruses

    Monica L. Zigman Suchsland, Ivan Rahmatullah, Barry Lutz, Victoria Lyon, Shichu Huang, Enos Kline, Chelsey Graham, Shawna Cooper, Philip Su, Sam Smedinghoff, Helen Y. Chu, Kara Sewalk, John S. Brownstein & Matthew J. Thompson
    BMC infectious diseases 21 (1), 1-12 (June 29, 2021)
    https://doi.org/10.1186/s12879-021-06314-1

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    Flu@home: The comparative accuracy of an at-home influenza rapid diagnostic test, using a pre-positioned test kit, mobile app, mail-in reference sample, and symptom-based testing trigger

    Jack Henry Kotnik, Shawna Cooper, Sam Smedinghoff, Piyusha Gade, Kelly Scherer, Mitchell Maier, Jessie Juusola, Ernesto Ramirez, Pejman Naraghi-Arani, Victoria Lyon, Barry Lutz, Matthew Thompson.
    Journal of Clinical Microbiology.
    10.1128/JCM.02070-21.

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    Harmony COVID-19: A ready-to-use kit, low-cost detector, and smartphone app for point-of-care SARS-CoV-2 RNA detection

    Nuttada Panpradist, Enos C. Kline, Robert G. Atkinson, Michael Roller, Qin Wang, Ian T. Hull, Jack H. Kotnik, Amy K. Oreskovic, Crissa Bennett, Daniel Leon, Victoria Lyon, Shane D. Gilligan-Steinberg, Peter D. Han, Paul K. Drain, Lea M. Starita, Matthew J. Thompson, Barry R. Lutz.
    Science Advances 7(51): (2021).


     

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    Rapid Near Point-of-Care Assay for HLA-B*57:01 Genotype Associated with Severe Hypersensitivity Reaction to Abacavir

    Wallner JJ, Beck IA, Panpradist N, Ruth PS, Valenzuela-Ponce H, Soto-Nava M, Ávila-Ríos S, Lutz BR, Frenkel LM. Rapid Near Point-of-Care Assay for HLA-B*57:01 Genotype Associated with Severe Hypersensitivity Reaction to Abacavir.
    AIDS Res Hum Retroviruses. 2021 Dec;37(12):930-935.
    doi: 10.1089/AID.2021.0103. Epub 2021 Nov 30. PMID: 34714103; PMCID: PMC8716482.

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    Diagnosing pulmonary tuberculosis using sequence-specific purification of urine cell-free DNA

    Amy Oreskovic, Nuttada Panpradist, Diana Marangu, M. William Ngwane, Zanele P. Magcaba, Sindiswa Ngcobo, Zinhle Ngcobo, David J. Horne, Douglas P.K. Wilson, Adrienne E. Shapiro, Paul K. Drain, Barry R. Lutz.
    Journal of Clinical Microbiology 59(8):e00074-21 (2021)
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    Multivalent designed proteins protect against SARS-CoV-2 variants of concern

    Andrew C. Hunt, James Brett Case, Young-Jun Park, Longxing Cao, Kejia Wu, Alexandra C. Walls, Zhuoming Liu, John E. Bowen, Hsien-Wei Yeh, Shally Saini, Louisa Helms, Yan Ting Zhao, Tien-Ying Hsiang, Tyler N. Starr, Inna Goreshnik, Lisa Kozodoy, Lauren Carter, Rashmi Ravichandran, Lydia B. Green, Wadim L. Matochko, Christy A. Thomson, Bastain Vögeli, Antje Krüger-Gericke, Laura A. VanBlargan, Rita E. Chen, Baoling Ying, Adam L. Bailey, Natasha M. Kafai, Scott Boyken, Ajasja Ljubetič, Natasha Edman, George Ueda, Cameron Chow, Amin Addetia, Nuttada Panpradist, Michael Gale Jr, Benjamin S. Freedman, Barry R. Lutz, Jesse D. Bloom, Hannele Ruohola-Baker, Sean P. J. Whelan, Lance Stewart, Michael S. Diamond, David Veesler, Michael C. Jewett, David Baker
    https://doi.org/10.1101/2021.07.07.451375

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    Implementation of an interactive mobile application to pilot a rapid assay to detect HIV drug resistance mutations in Kenya

    Justin D. Vrana, Nuttada Panpradist, Nikki Higa, Daisy Ko, Parker Ruth, Ruth Kanthula, James J. Lai, Yaoyu Yang, Samar R. Sakr, Bhavna Chohan, Michael H. Chung, Lisa M. Frenkel, Barry R. Lutz, Eric Klavins, Ingrid A. Beck
    medRxiv 2021.05.06.21256654;
    https://doi.org/10.1101/2021.05.06.21256654

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    Ultrasensitive hybridization capture: Reliable detection of <1 copy/mL short cell-free DNA from large-volume urine samples

    Amy Oreskovic, Barry R Lutz. PLOS ONE 16(2): e0247851 (2021)

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    Simpler and faster Covid-19 testing: Strategies to streamline SARS-CoV-2 molecular assays

    Nuttada Panpradist, Qin Wang, Parker S. Ruth, Jack H. Kotnik, Amy K. Oreskovic, Abraham Miller, Samuel W.A. Stewart, Justin Vrana, Peter D. Han, Ingrid A. Beck, Lea M. Starita, Lisa M. Frenkel, Barry R. Lutz.
    EBioMedicine, Volume 66, April 2021, Pages 103296

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    Urine Biomarker Assessment of Infant Adherence to Isoniazid Prophylaxis

    LaCourse SM, Leon D, Panpradist N, Richardson BA, Maleche-Obimbo E, Mecha J, Matemo D, Escudero JN, Kinuthia J, Lutz B, John-Stewart G. Urine Biomarker Assessment of Infant Adherence to Isoniazid Prophylaxis. Pediatr Infect Dis J. 2021 Jan;40(1):e43-e45.

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    Near point-of-care, point-mutation test to detect drug resistance in HIV-1: a validation study in a Mexican cohort

    Nuttada Panpradist 1,2 *, Ingrid A. Beck 3 *, Parker S. Ruth 1,4 , Santiago Avilla-Rios 5, Claudia Garcia-Morales 5 , Maribel Soto-Nava 5 , Daniela Tapia-Trejo 5 , Margarita Matias-Florentino 5, Hector E. Paz-Juarez 5, Silvia del Arenal-Sanchez 5, Gustavo Reyes-Teran 5 , Barry R. Lutz 1§ , Lisa M Frenkel 3,6. AIDS (in press).

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    The Seattle Flu Study: a multi-arm community-based prospective study protocol for assessing influenza prevalence, transmission, and genomic epidemiology

    Helen Y Chu, Michael Boeckh, Janet A Englund, Michael Famulare, Barry R Lutz, Deborah A Nickerson, Mark J Rieder, Lea M Starita, Amanda Adler, Elisabeth Brandstetter, Chris D Frazar, Peter D Han, Reena K Gularti, James Hadfield, Michael L Jackson, Anahita Kiavand, Louise E Kimball, Kirsten Lacombe, Jennifer Logue, Victoria Lyon, Kira L Newman, Thomas R Sibley, Monica L Zigman Suschsland, Caitlin Wolf, Jay Shendure, Trevor Bedford. medRxiv (repository during peer review).

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    OLA-Simple: A software-guided HIV-1 drug resistance test for low-resource laboratories

    Nuttada Panpradist, Ingrid A Beck, Justin Vrana, Nikki Higa, David McIntyre, Parker S. Ruth, Isaac So, Enos C. Kline, Ruth Kanthula, Annie Wong-On-Wing, Jonathan Lim, Daisy Ko, Ross Milne, Theresa Rossouw, Ute D Feucht, Michael Chung, Gonzague Jourdain, Nicole Ngo-Giang-Huong, Laddawan Laomanit, Jaime Soria, James Lai, Eric D. Klavins, Lisa M. Frenkel, Barry R. Lutz. EBioMedicine (published by The Lancet) 50, 34-44, 2 (2019). Editorial discussion by Marc Noguera-Julian (HIV drug resistance testing – the quest for point-of-care”).

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    Analytical Comparison of Methods for Extraction of Short Cell-Free DNA from Urine

    A. Oreskovic, ND Brault, N. Panpradist, JJ Lai, BR Lutz. The Journal of Molecular Diagnostics 21 (6), 1067-1078 2 2019

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    1775. A Community-wide Study to Evaluate the Accuracy of Self-testing for Influenza: Works in Progress

    Matthew Thompson, Monica L. Zigman Suchsland, Victoria Lyon, Enos Kline, ShiChu Huang, Helen Y. Chu, Mark Rieder, Lea Starita, Jeris Bosua, Barry R. Lutz. Open Forum Infectious Diseases, 6 Supplement 2, S654-S654 (2019)

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    Threshold-Based Quantification in a Multiline Lateral Flow Assay via Computationally Designed Capture Efficiency

    DJ Gasperino, D Leon, B Lutz, DM Cate, KP Nichols, D Bell, BH Weigl. Analytical chemistry 90 (11), 6643-6650 (2018)

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    Frequency characterization of flow magnitude and phase in resonant microfluidic circuits

    Rahil Jain, Robert B. Darling and Barry Lutz Analytical Methods (2017)

     

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    Flow control using audio tones in resonant microfluidic networks: towards cell-phone controlled lab-on-a-chip devices

    Reid Phillips, Rahil Jain, Yoni Browning, Rachana Shah, Peter Kauffman, Doan Dinh and Barry Lutz. Lab on a Chip (2016)

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    Simplified paper format for detecting HIV drug resistance in clinical specimens by oligonucleotide ligation

    Nuttada Panpradist, Ingrid Beck, Michael Chung, James Kiarie, Lisa Frenkel and Barry Lutz. PLoS ONE (2016)

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    Isothermal Strand Displacement Amplification (iSDA): A Rapid and Sensitive Method of Nucleic Acid Amplification for Point-of-Care Diagnosis

    Bhushan Toley, Isabela Covelli, Yevgeniy Belousov, Sujatha Ramachandran, Enos Kline, Noah Scarr, Nic Vermeulen, Walt Mahoney, Barry Lutz and Paul Yager. Analyst (2015)

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    One-step purification and concentration of DNA in porous membranes for point-of-care applications

    Samantha Byrnes, Josh Bishop, Lisa Lafleur, Josh Buser, Barry Lutz and Paul Yager Lab on a Chip (2015)

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    A versatile valving toolkit for automating fluidic operations in paper microfluidic devices

    Bhushan Toley, Jessica Wang, Mayuri Gupta, Josh Buser, Lisa Lafleur, Barry Lutz, Elain Fu and Paul Yager Lab on a Chip (2015)

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    Swab Sample Transfer for Point-Of-Care Diagnostics: Characterization of Swab Types and Manual Agitation Methods

    Nuttada Panpradist, Bhushan Toley, Xio Zhang, Sam Byrnes, Josh Buser, Janet Englund and Barry Lutz PloS ONE (2014)

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    Long-term dry storage of an enzyme-based reagent system for ELISA in point-of-care devices

    Sujatha Ramachandran, Elaine Fu, Barry Lutz and Paul Yager. Analyst (2014)

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    Dissolvable fluidic time delays for programming multi-step assays in instrument-free paper diagnostics

    Barry Lutz, Tinny Liang, Elaine Fu, Sujatha Ramachandran, Peter Kauffman and Paul Yager. Lab on a Chip (2013)

    Subject of a “Viewpoints” article by George Whitesides, Lab on a Chip (2013), DOI: 10.1039/C3LC90066e. Also featured in Chemistry World, May 30, 2013, ”Microfluidic sugar paper” with quotes from George Whitesides

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    A Rapid, Multiplexed, High-Throughput Flow-Through Membrane Immunoassay: A Convenient Alternative to ELISA

    Sujatha Ramachandran, Mitra Singhal, Katherine McKenzie, Jennifer L. Osborn, Amit Arjyal, Sabina Dongol, Stephen Baker, Buddha Basnyat, Jeremy Farrar, Christiane Dolecek, Gonzalo J. Domingo, Paul Yager and Barry Lutz. Diagnostics, Special Issue: Feature Papers (2013),

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    Progress toward multiplexed sample-to-result detection in low resource settings using microfluidic immunoassay cards

    Lisa Lafleur, Dean Stevens, Katherine McKenzie, Sujatha Ramachandran, Paolo Spicar-Mihalic, Mitra Singhal, Amit Arjyal, Jennifer Osborn, Peter Kauffman, Paul Yager and  Barry Lutz. Lab on a Chip (2012)

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    New and Improved Ways to Treat Hydrocephalus: pursuit of a smart shunt

    Barry Lutz, Pranav Venkataraman and Sam Browd. Surgical Neurology International (2013)

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    Two-dimensional paper networks: programmable fluidic disconnects for multi-step processes in shaped paper

    Barry Lutz, Philip Trinh, Cameron Ball, Elaine Fu and Paul Yager. Lab on a Chip (2011)

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    Enhanced Sensitivity of Lateral Flow Tests Using a Two-Dimensional Paper Network Format

    Elain Fu, Tinny Liang, Jared Houghtaling, Sujatha Ramachandran, Stephen A. Ramsey, Barry Lutz and Paul Yager. Analytical Chemistry (2011)

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    Transport in two-dimensional paper networks

    Elain Fu, Stephen Ramsey, Peter Kauffman, Barry Lutz and Paul Yager Microfluidics and Nanofluidics (2011)

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    Microfluidics without pumps: re-inventing the T-sensor & H-filter in paper networks

    Jennifer Osborn, Barry Lutz, Elain Fu, Peter Kauffman, Dean Y. Stevensa and Paul Yager Lab on a Chip (2010)

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    Chemical signal amplification in two-dimensional paper networks

    Elain Fu, Peter Kauffman, Barry Lutz, Paul Yager. Sensors & Actuators B (2010)

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    Visualization and measurement of flow in two-dimensional paper networks

    Peter Kauffman, Elain Fu, Barry Lutz and Paul Yager. Lab on a Chip (2010)

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    Controlled reagent transport in disposable 2D paper networks

    Elain Fu, Barry Lutz, Peter Kauffman and Paul Yager. Lab on a Chip (2010)

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    Rapid protein depletion from complex samples using a bead-based microfluidic device for the point of care

    Katherine McKenzie, Lisa Lafleur, Barry Lutz and  Paul Yager. Lab on a Chip (2009)

  • People

    Current lab members

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    Barry Lutz

    Associate Professor

    Ph.D. Chemical Engineering

    Office: Foege N530N
    Phone: (206) 685-9891
    ResearchGate Profile

    Email
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    Garima Thakur

    Lab Manager, Research Scientist

    Ph.D. Chemistry
    Office: Foege N209B
    Phone: (206) 543-7331
    ResearchGate Profile

    Email
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    Enos Kline

    Research Scientist

    Protein engineering and assay design; HIV drug resistance, HIV self-test, Engineered polymerase, Harmony COVID-19 test
    ResearchGate Profile

    Email
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    Jason Rupp

    Data Scientist

    Project: Data-Enhanced Diagnostics
    LinkedIn Profile

    Email
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    Shane Gilligan-Steinberg

    BioE Ph.D. Student

    HIV Self-Test

    LinkedIn Profile
    Google Scholar Profile

    ResearchGate Profile

    Email
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    Joe Henthorn

    Ph.D. Student in MolES, Research Assistant

    HIV Self-test
    LinkedIn Profile

    Email
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    Rhett Britton

    BioE Ph.D. Student

    TB Drug-resistance
    LinkedIn Profile
    ResearchGate Profile

    brittonr@uw.edu

    Email
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    Wookyeom Kim

    BioE Ph.D. Student

    TB cfDNA Capture project

    LinkedIn
    Google Scholar Profile

    Email
  • Former Members


    Leila Ahmadinia, Research Scientist, OLA-Simple
    Bob Atkinson, Point-of-care multiplexable nucleic acid assay for STDs

    Crissa Bennett, Research Scientist, COVID test development, TB cfDNA project, Current: Anavasi Diagnostics
    Jordan Campbell, Research Assistant, OLA-Simple - HIV Drug Resistance Test

    Daniel Leon, CrossLife TARA detection projects, TB-drug adherence at-home monitoring project

    Ria Sonigara, Graduate Student, Indian Institute of Technology (BHU), OLA-Simple – HIV Drug Resistance Test
    Sam Stewart, Research Scientist, OLA-Simple – HIV Drug Resistance Test

    2024 Graduates

    Qin Wang, BioE Ph.D. Student, HIV Self-test

    2023 Graduates

    Ian Hull, Ph.D. Student, Polymerase engineering for direct nucleic acid diagnostics

    2022 Graduates

    Nuttada Panpradist, Ph.D. student, OLA-Simple – HIV Drug Resistance Test, Post-doctoral Fellow, OLA-Simple – HIV Drug Resistance Test Currently Assistant Professor at UT Austin BME - PANDA Lab

    Jack Henry Kotnik, Research Scientist, Assay design, TARA Project; automated lateral flow strip interpretation; comparative accuracy of rapid diagnostic tests

    2021 Graduates

    Amy Oreskovic, Ph.D. student, (TB diagnosis from urine cell-free DNA)

    2019 Graduates

    Zachary McNulty, Undergraduate Student (Point-of-care pulmonary TB detection using urine)

    2018 Graduates

    Jonathan Lim, Undergraduate Student (Point-of-care pulmonary TB detection using urine)

    David McIntyre, Undergraduate Student (OLA-Simple - HIV Drug Resistance Test)

    Rahil Jain, EEPh.D. Candidate

    Annapurni Sriram, Undergraduate Student (OLA-Simple - HIV Drug Resistance Test)

    Rosemichelle Marzan, Undergraduate Student, (Collaboration Project with Global Good)

    2017 Graduates

    Nikka Higga, BioE Senior Capstone Student (OLA-Simple), Currently at Seattle Children's Hospital
    Bella Spielman, BioE Senior Capstone Student (OLA-Simple), Currently at Accenture
    Annie Wing-on-Wong, BioE Senior Capstone Student (OLA-Simple), Currently at Seattle Children's Hospital

    2016 Graduates

    Ian Andrews, BioE Senior Capstone Student (OLA-Simple), Currently at MIT
    Doan Dinh, BioE Senior Capstone Student (Lab on a phone call project), Currently at Physio-Control

    2015 and before

    Yoni Browning. Undergraduate Student (AC Fluidics Project)

    Damon Cassisi. Research Engineer (Smart Shunt Project)

    Bibianna Cha, Research Engineer (Smart Shunt Project)
    Shivani Dharmaraja, Masters Student (Point-of-Care Diagnostics for HIV)

    Marie Eberlein, BioE Senior Capstone Student (AC Fluidics Project)
    Ricky Liu, BioE Senior Capstone Student (Capillary-driven Point-of-Care Diagnostics, collaboration with Deok-Ho Kim)
    Madhav Murthy, Undergraduate Researcher (Point-of-Care Diagnostics for HIV)

    Reid Philips. BioE Senior Capstone Student (AC Fluidics Project)
    Joel Relethford, Research Engineer (Smart Shunt Project)

    Rachana Shah. Graduate Student, MS 2010 (AC Fluidics Project)
    Pranav Venkataraman, BioE Senior Capstone Student (Smart Shunt Project)
    Chenyi Wang, BioE Senior Capstone Student (Smart Shunt Project)
    James Wong. BioE Senior Capstone Student (AC Fluidics Project, Protein Printing)

  • Archived News

    Updates from the inside and around the lab

    2022

    December

    Wookyeom Kim joins Lutz Lab

    Wookyeom received a bachelor's degree in mechanical engineering from Pusan National University and a master's degree in mechanical engineering from POSTECH in South Korea. He studied Lung-on-a-chip, which cultures inkjet bioprinted human alveolar models.

    When he went to a low medical resources country to deliver medical services, he witnessed the majority of patients just going back with some painkillers instead of appropriate treatment due to the absence of diagnostic equipment for a low-resource setting. Ever since the visit, Wookyeom has been dreaming of developing an innovative point-of-care testing method so that anyone can receive appropriate treatment. His research interest involves the development of a tuberculosis cfDNA capturing method from accessible liquid biopsies such as urine.

    Out of the lab, Wookyeom enjoys playing tennis and cooking.
     

    Rhett Britton joins Lutz Lab

    Rhett is from Nashville, Tennessee, and earned his B.E. in Biomedical Engineering from Vanderbilt University in 2020. His undergraduate research included projects in structural biology and microfluidics.

    After graduation, Rhett worked as a research assistant in the Chilkoti lab at Duke University where he developed rapid point-of-care COVID-19 antigen assays. His long-term interest in diagnostic technologies intended for low-resource settings around the globe led him to join the Lutz lab in 2022. He is currently working on the development of an assay to detect drug-resistant tuberculosis strains from urine cell-free DNA.

     

    Outside of the lab, Rhett loves to travel, hike, kayak, play piano and ukulele, and cheer on the Nashville Predators and Tennessee Titans.


    February 7

    Nuttada Panpradist featured on UW Bioengineering News: "New Ph.D. grad Nuttada Panpradist ready for next challenge: faculty position"

    Having successfully defended her Ph.D. in Dec. 2021, Nuttada is featured on her accomplishments and contributions to UW Bioengineering as a Ph.D. student, and her contributions to the success of the Lutz Lab. She is recognized for having the "heart of a leader".

    Follow Nuttada's journey:
    Nuttada's website
    Nuttada's blog


    January 24

    Featured on Local Newscast for Harmony Kit COVID-testing

    Dr. Lutz is the senior author on a paper published Dec. 15 in Science Advances that describes the Harmony COVID-19 test kit. The team developed Harmony to be simple and easy-to-use, employing ready-to-use reagents. The test uses a “PCR-like” method to detect the presence of the SARS-CoV-2 RNA genome in a nasal swab sample with the aid of a small, low-cost detector, which was also designed by the Lutz Lab. A smartphone is used to operate the detector and read the results. The detector can handle up to four samples at a time and would fit into a standard car’s glove compartment.

     

    2021

    August 16

    $14.9M Awarded to Lutz Lab’s COVID-19 Technology Company

    Anavasi Diagnostics, a company recently founded out of Professor Barry Lutz’s lab at the University of Washington, announced it has been awarded $14.9 million from the National Institutes of Health (NIH) Rapid Acceleration of Diagnostics (RADxSM) initiative. The funding will accelerate the launch and broad market availability of the AscencioDx™ molecular diagnostic platform for the detection of RNA indicative of the SARS-CoV-2 / COVID-19 virus.


    The project was initiated less than a year ago and advanced quickly with coaching and support from the WE-REACH team and the NIH RADx initiative. Learn more about the exciting journey this team has been on as they moved their technology from university-based research to a funded commercial enterprise.



    August 16

    Read about the SARS-CoV-2 technology developed from Lutz lab @uwbioe MedRxiv. A novel four-plexed RT-LAMP test kit operated by health workers can provide faster and more sensitive results than lab tests. https://www.medrxiv.org/content/10.1101/2021.08.12.21261875v1.full.pdf+html


    August 9

    Garima Thakur Hired As Lutz Lab Manager
    Garima graduated with Ph.D. in chemistry at the University of Miami, FL, and worked as a CERC post-doctoral fellow at the University of Alberta, Canada. Before joining Lutz lab as lab operations manager/research scientist, she worked as Lab & Research Director at SoundBio Lab, Seattle. She's excited to join Lutz Lab and will work on lab operations and conduct research.

    The motivation for her research is her intellectual drive toward smaller dimensions to explore size-dependent novel properties and phenomena. Over the past 13 years, Garima'ss research focus has been on nanotechnology to design and develop complex biomolecular smart materials for biosensing and biomedical research applications. Her background in research includes surface chemistry, protein self-assembly, protein aggregation, nanomaterials, biosensing using nanomechanical deflection, and spectroscopic methods for the benefit of biotechnology. Garima's primary research contributions involve, but are not limited to inhibition of amyloid beta fibrillation, Langmuir monolayer models for lipid raft research, protein patterning, self-assembled hydrogels, and nanomechanical deflection sensing for point-of-care diagnostics.

    Garima volunteers for SoundBio and ACS Puget Sound Section as a member of the Diversity Equity Inclusion and Respect (DEIR) Committee and Women Chemist Committee (WCC) in her free time. She was recently nominated as an Alternate Councillor at ACS Puget Sound Section of ACS. Another of Garima's passions is to create workshops or courses for a wider audience and she enjoys reviewing journal articles for peer-reviewed journals.



    June 10

    Nuttada Panpradist Receives UW College of Engineering Award
    Nuttada Panpradist’s impressive academic career includes 13 publications, 17 conference proceedings, and four patent applications. Her simple point-of-care tests detect HIV genetic mutations to help doctors prescribe non-resistant drugs. She designed rapid lab tests for COVID-19 and devices to ensure patients are taking their TB medication. She has collaborated with various researchers on COVID-19 projects such as developing new methods to detect SARS-CoV-2 in Seattle to validating point-of-care tests in pediatric clinics. As a mentor, Panpradist connects undergraduate students with research projects that match their interests. All her students have received research scholarships and are named co-authors and co-inventors of patents. “Nuttada has gone above and beyond to foster our new collaboration; beyond her scientific acumen, she is an attentive and professional partner, mature beyond her years, conscientious, flexible, able to balance multiple responsibilities, and has an impressive work ethic.”


    June 9

    Lutz Lab's Nuttada Panpradist will join an expert panel at today's WE-REACH fireside chat to discuss biomedical business models, budgets, and funding sources. https://www.seattleangelconference.com


    Other experts who will be on the panel are:

    • John Sechrest, CEO, Seattle Angel Conference

    • Elizabeth Cross Nichol, APIS Health Angels, Seattle

    • Minda Brusse, First Row Partners, Seattle


    Previously Lutz Lab received funding from WE-REACH to support the commercialization of the point-of-care COVID-19 test.

    Read here.



    June 7
    Congratulations to Nuttada for being recognized for outstanding contributions to UW Bioengineering research! The UW College of Engineering Awards acknowledged the extraordinary efforts of the college’s teaching and research assistants, staff and faculty members.

    Nuttada Panpradist’s impressive academic career includes 13 publications, 17 conference proceedings, and four patent applications. Her simple point-of-care tests detect HIV genetic mutations to help doctors prescribe non-resistant drugs. She designed rapid lab tests for COVID-19 and devices to ensure patients are taking their TB medication. She has collaborated with various researchers on COVID-19 projects such as developing new methods to detect SARS-CoV-2 in Seattle to validating point-of-care tests in pediatric clinics. As a mentor, Panpradist connects undergraduate students with research projects that match their interests. All her students have received research scholarships and are named as co-authors and co-inventors of patents. “Nuttada has gone above and beyond to foster our new collaboration; beyond her scientific acumen, she is an attentive and professional partner, mature beyond her years, conscientious, flexible, able to balance multiple responsibilities, and has an impressive work ethic.”

    05/26
    Amy passed her Ph.D. defense, titled "Improving diagnosis of tuberculosis from urine cell-free DNA." Congratulations Amy!"

    02/01
    Nuttada's paper from 2014 on swabs for point-of-care testing is getting a lot of attention lately. She characterized the release of samples from different nasal swab types, including the effect of manual agitation and a novel design for flow-through swabs - very relevant today for Covid testing. She is working on a follow-up paper - coming soon!

    2020

    03/27
    The Lutz group is recruiting postdoctoral researchers and research engineers to develop novel point-of-care diagnostics for global health and home testing. We have multiple projects in areas of HIV, respiratory infection (including Covid-19), and other infectious diseases. We are looking for strong thinkers who can contribute in the following areas:

    • Point of care device engineering (mechanical prototyping, optical detection, low-cost electrical design)
    • Development of novel assays (RNA/DNA detection, nucleic acid amplification)

    Please send your CV to Dr. Lutz with the subject “Lutz Lab Hiring 2020”

    2018

    03/08

    Rahil passed his defense. Congratulations!

     

    03/01

    OLA Simple won the 2nd place $10k award at the annual Health Innovation Challenge

    https://www.geekwire.com/2018/student-entrepreneurs-tackle-genetic-testing-clinical-trials-health-startup-competition/

    2017

    09/09

    Dr. Lutz traveled to Nepal as part of a Bioengineering department group to make ties to Kathmandu University.

     

    09/01

    Rahil's paper on the flow magnitude and phase measurement in resonant devices is published and selected to be featured on the Front Cover of the Journal Analytical Methods.

     

    http://pubs.rsc.org/en/content/articlelanding/2017/ay/c7ay01699a#!divAbstract

     

    08/22 - 09/15

    Rahil got the Amazon Catalyst grant ($50k) and the GIX Innovation Award ($20k) to further work on commercializing his side projects.

     

    08/15

    Dr. Nathan White (UW, Emergency medicine) and Dr. Lutz submitted a new collaboration grant to work on a smartphone-powered thromboelastography device based on the resonant microfluidics project.

     

    07/14

    Nuttada received the prestigious 2017 UW Medicine Bud Tribble and Susan Barnes Graduate Discovery Fellowship. To learn more: https://bioe.uw.edu/nuttada-panpradist-receives-graduate-discovery-fellowship/

     

    05/01

    Rahil's paper featured on the Front Cover of the Journal Lab on a Chip Volume 17 Number 9

    http://pubs.rsc.org/en/content/articlelanding/2017/lc/c7lc90043k#!divAbstract

    News article - https://bioe.uw.edu/ph-d-student-rahil-jain-investigates-smart-solutions-for-diagnostics-home-electronics/

     

    04/27

    Nuttada passed her Generals! Congratulations!

     

    03/06

    Dr. Lutz traveled to Bangladesh to experience the global health needs first-hand.

     

    02/06

    Nuttada and her OLA-Simple team were featured on KIRO NEWS

    https://www.engr.washington.edu/news/panpradist

     

    01/28

    Rahil passed his Generals. Congratulations!

    2016

    08/31

    Congratulation to Nuttada and Rahil for being selected as 10 finalists around the nation for the APF Student Technology Prize for Primary Healthcare. The competition, administered by Massachusetts General Hospital's Ambulatory Practice of the Future (APF) and sponsored by the Gelfand Family Charitable Trust, encourages and supports engineering students' efforts to develop innovative, clinically-relevant primary health care technology concepts.

     

    06/10

    Congratulations to Doan and Ian on graduating. Ian made it to coveted Husky 100 and is heading to MIT for graduate school. Doan will be working with Physio Control in Redmond WA. Good luck to you both.

     

    05/12 

    Congratulations to Nuttada and Rahil to make it final round of APF Student Technology Prize. Both are independently getting $10k to further their research. Final proposals are due Aug 29.

     

    03/11

    Congratulations to Annie on receiving Mary Gates Research Scholarship!

     

    02/12

    Nuttada and Dr. James Lai (our collaborator on the OLA-Simple Project) wrote a chapter on point-of-care diagnostics as part of the book titled "Biomaterials Nanoarchitectonics" edited by Mitsuhiro Ebara. The book has just been published and now available at Elsevier website and can be downloaded via the UW library.

     

    02/01

    Bioengineer sophomore Jonathan Lim joined the Lutz Lab and will work on the TB project. Welcome Jonathan!!!

     

    01/11

    Nuttada's manuscript in PLoS ONE! "Simplified paper format for detecting HIV drug resistance in clinical specimens by oligonucleotide ligation" - see publications

     

    02/20 - 02/21

    Nuttada, Annie, Ian and Nikki are presenting at the XXV International HIV Drug Resistance Workshop in Boston, MA (a closed workshop, with a limited attendance of 200 delegates). Stop by and check out their poster presentations in the New Resistance Technologies and Interpretations Session!

     

    01/20

    Nuttada is co-lecturing with Dr. Sylvia LaCourse in the GH590 Global WACh BioEngineering Seminar on "Opportunities for Point-of-care TB Diagnostics" Come by at 4:30 - 5:30 PM at EEB 037 in the Electrical Engineering Building!

     

    01/04 - 03/11

    Dr. Lutz is teaching the Global Health Technology: Molecular Diagnostics!

     

    01/04 - 03/11

    Nuttada is TAing for BIOEN 531 Proposal Writing by Dr. Marta Scatena - one of the three Bioengineering Graduate Core classes! She is teaching a class on oral presentation and grant reviewing process on the Feb 8th, 2015.

  • Contact us

    Inquiries or correspondence should be sent to:

     

    Barry Lutz

    blutz @ uw.edu

    University of Washington

    Department of Bioengineering

    3720 15th Avenue NE

    Box 355061

    Seattle WA 98195

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