Lutz Lab
Point-of-care diagnostics for
global health
News
Updates from the inside and around the lab
Nuttada Panpradist Receives UW College of Engineering Award
2021
August 16
Read about the SARS-CoV-2 technology developed from Lutz lab @uwbioe MedRxiv. A novel four-plexed RT-LAMP test kit operated by health workers can provide faster and more sensitive results than lab tests. https://www.medrxiv.org/content/10.1101/2021.08.12.21261875v1.full.pdf+html
June 9Lutz Lab's Nuttada Panpradist will join an expert panel at today's WE-REACH fireside chat to discuss biomedical business models, budgets, and funding sources. https://www.seattleangelconference.com
Other experts who will be on the panel are:• John Sechrest, CEO, Seattle Angel Conference
• Elizabeth Cross Nichol, APIS Health Angels, Seattle
• Minda Brusse, First Row Partners, Seattle
Previously Lutz Lab received funding from WE-REACH to support the commercialization of the point-of-care COVID-19 test.
June 7
Congratulations to Nuttada for being recognized for outstanding contributions to UW Bioengineering research! The UW College of Engineering Awards acknowledged the extraordinary efforts of the college’s teaching and research assistants, staff and faculty members.
Nuttada Panpradist’s impressive academic career includes 13 publications, 17 conference proceedings, and four patent applications. Her simple point-of-care tests detect HIV genetic mutations to help doctors prescribe non-resistant drugs. She designed rapid lab tests for COVID-19 and devices to ensure patients are taking their TB medication. She has collaborated with various researchers on COVID-19 projects such as developing new methods to detect SARS-CoV-2 in Seattle to validating point-of-care tests in pediatric clinics. As a mentor, Panpradist connects undergraduate students with research projects that match their interests. All her students have received research scholarships and are named as co-authors and co-inventors of patents. “Nuttada has gone above and beyond to foster our new collaboration; beyond her scientific acumen, she is an attentive and professional partner, mature beyond her years, conscientious, flexible, able to balance multiple responsibilities, and has an impressive work ethic.”
05/26
Amy passed her Ph.D. defense, titled "Improving diagnosis of tuberculosis from urine cell-free DNA." Congratulations Amy!"
02/01
Nuttada's paper from 2014 on swabs for point-of-care testing is getting a lot of attention lately. She characterized the release of samples from different nasal swab types, including the effect of manual agitation and a novel design for flow through swabs - very relevant today for Covid testing. She is working on a follow-up paper - coming soon!Positions available with Lutz Labs
The Lutz group is recruiting postdoctoral researchers and research engineers to develop novel point-of-care diagnostics for global health and home testing. We have multiple projects in areas of HIV, respiratory infection (including Covid-19), and other infectious diseases. We are looking for strong thinkers who can contribute in the following areas:
- Point of care device engineering (mechanical prototyping, optical detection, low-cost electrical design)
- Development of novel assays (RNA/DNA detection, nucleic acid amplification)
Please send your CV to Dr. Lutz with the subject “Lutz Lab Hiring 2021”
Please send your CV to Dr. Lutz with the subject “Lutz Lab Hiring 2021”
Publications
Representative peer-reviewed journal publications
Ultrasensitive hybridization capture: Reliable detection of <1 copy/mL short cell-free DNA from large-volume urine samples
Diagnosing pulmonary tuberculosis using sequence-specific purification of urine cell-free DNA
Near point-of-care, point-mutation test to detect drug resistance in HIV-1: a validation study in a Mexican cohort
The Seattle Flu Study: a multi-arm community-based prospective study protocol for assessing influenza prevalence, transmission, and genomic epidemiology
OLA-Simple: A software-guided HIV-1 drug resistance test for low-resource laboratories
Analytical Comparison of Methods for Extraction of Short Cell-Free DNA from Urine
1775. A Community-wide Study to Evaluate the Accuracy of Self-testing for Influenza: Works in Progress
Threshold-Based Quantification in a Multiline Lateral Flow Assay via Computationally Designed Capture Efficiency
Frequency characterization of flow magnitude and phase in resonant microfluidic circuits
Frequency tuning allows flow direction control in microfluidic networks with passive features
Flow control using audio tones in resonant microfluidic networks: towards cell-phone controlled lab-on-a-chip devices
Simplified paper format for detecting HIV drug resistance in clinical specimens by oligonucleotide ligation
Isothermal Strand Displacement Amplification (iSDA): A Rapid and Sensitive Method of Nucleic Acid Amplification for Point-of-Care Diagnosis
One-step purification and concentration of DNA in porous membranes for point-of-care applications
A versatile valving toolkit for automating fluidic operations in paper microfluidic devices
Swab Sample Transfer for Point-Of-Care Diagnostics: Characterization of Swab Types and Manual Agitation Methods
Long-term dry storage of an enzyme-based reagent system for ELISA in point-of-care devices
Dissolvable fluidic time delays for programming multi-step assays in instrument-free paper diagnostics
Subject of a “Viewpoints” article by George Whitesides, Lab on a Chip (2013), DOI: 10.1039/C3LC90066e. Also featured in Chemistry World, May 30, 2013, ”Microfluidic sugar paper” with quotes from George Whitesides
A Rapid, Multiplexed, High-Throughput Flow-Through Membrane Immunoassay: A Convenient Alternative to ELISA
New and Improved Ways to Treat Hydrocephalus: pursuit of a smart shunt
Progress toward multiplexed sample-to-result detection in low resource settings using microfluidic immunoassay cards
Two-dimensional paper networks: programmable fluidic disconnects for multi-step processes in shaped paper
Enhanced Sensitivity of Lateral Flow Tests Using a Two-Dimensional Paper Network Format
Transport in two-dimensional paper networks
Microfluidics without pumps: re-inventing the T-sensor & H-filter in paper networks
Chemical signal amplification in two-dimensional paper networks
Visualization and measurement of flow in two-dimensional paper networks
Controlled reagent transport in disposable 2D paper networks
Rapid protein depletion from complex samples using a bead-based microfluidic device for the point of care
People
Current lab members
Barry Lutz
Assistant Professor
Bob Atkinson
BioE Ph.D. Student
Point-of-care multiplexable nucleic acid assay for STDs
Nuttada Panpradist
BioE Ph.D. Student
OLA-Simple – HIV Drug Resistance Test
Ian Hull
BioE Ph.D. Student
Daniel Leon
Research Engineer
CrossLife TARA detection projects
TB-drug adherence at-home monitoring project
